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Neurofisiología Celular - GNA

Neurofisiología

Celular

Prof. Rafael Posada-Duque
Equipo Neurofisiología

Objetivo

Entender las bases neurofisiológicas de la memoria y aprendizaje en vertebrados; y los mecanismos fisiopatológicos del deterioro cognitivo.

  • Entender las bases neurofisiológicas de la memoria y aprendizaje en vertebrados: humanos y aves.
  • Entender los mecanismos fisiopatológicos del deterioro cognitivo en AD y CADASIL a nivel gliovascular (GVU)
  • Entender los mecanismos de resistencia a enfermedades neurodegenerativas a nivel gliovascular
  • Desarrollar moléculas sintéticas hibridas (SH) patentables utilizando modelos preclínicos para el tratamiento del AD.
  • Formación doctoral y entrenamiento posdoctoral.
  • Formación estudiantes de Maestría, y pregrado (Jóvenes Investigadores).
  • Formación experimental en Microscopía confocal y electrofisiológica en posgrado de Biología y CCBB.
  • Promover internacionalización de la formación.
  • Servicios de microscopía confocal, procesamiento y análisis de imágenes confocales y tissue scanner.
  • Diseño, síntesis y screenning de moléculas posiblemente neuroprotectores in vitro.

Department of Ophthalmology Harvard Medical School.
Joseph F Arboleda-Velasquez
Boston, Massachusetts

BNI/ Universidad de Chile
Sttefen Hartel
Santiago, Chile

Penn University
Diana Castaño, Senior Research
Philadelphia, USA

University of Sherbrooke.
Karl Fernandes.
Facultad de Medicina y Ciencias de la Salud.
Sherbrooke, Canadá

Proyectos

The neurovascular unit and the hypothalamus: assessing dysfunction in the hypothalamus of Alzheimer’s disease. IBRO Collaborative Research Grant 2023-2024.

Resistencia al Alzheimer. Good Ventures. 2025.

CRP - ICGEB Research Grants Programme 2021. Extracellular vesicles in Rheumatoid arthritis".

Modelo predictivo multifactorial del desarrollo de artritis reumatoide basado en la expresión de retrovirus endógenos humanos.

ÁREAS DE INTERÉS

Neurobiología del canto de las aves
Resistencia y protección vascular en AD y CADASIL
Desarrollo de moléculas sintéticas para el tratamiento de enfermedades neurodegenerativas

Publicaciones

Atehortúa, L., Rojas, M., Vásquez, G., Muñoz-Vahos, CH., Vanegas-García A, Posada-Duque R, Diana Castaño. Endothelial activation and injury by microparticles in patients with systemic lupus erythematosus and rheumatoid arthritis. (2019). Arthritis research & therapy. 21, 34. - https://doi.org/10.1186/s13075-018-1796-4

Villar-Vesga JM**, Henao-Restrepo J**, Voshart, Aguillón D, Villegas A, Castaño D, Arias-Londoño J, Zuhorn, Ribosvki, Barazzuol L, Cardona-Gómez GP and Posada-Duque R. Differential profile of systemic extracellular vesicles from sporadic and familiar Alzheimer’s disease leads to neuroglial and endothelial cell degeneration. (2020). Frontiers in Aging Neurosciences. - https://doi.org/10.3389/fnagi.2020.587989

González-Molina LA**, Villar-Vesga J, Henao-Restrepo J, Villegas A, Lopera F, Cardona-Gómez GP, Posada-Duque R. Extracellular vesicles from 3xTg-AD mouse and Alzheimer’s disease patient astrocytes impair neuroglial and vascular components. (2021) Frontiers in Aging Neurosciences.;593927 - https://doi.org/10.3389/fnagi.2021.593927

Toro-Fernandez LF**, Zuluaga-Monares JC**, Saldarriaga-Cartagena AM**, Cardona-Gómez GP, Posada-Duque R. Targeting CDK5 in astrocytes promotes calcium homeostasis under excitotoxic condition. (2021) Frontiers Cellular Neuroscience. 103389. - https://doi.org/10.3389/fncel.2021.643717

Novel Multipotent Amantadine–M30D Hybrids with Highly Selective Butyrylcholinesterase Inhibition and Neuroprotective Effects as Effective Anti-Alzheimer’s Agents. (2022). Rada, Marlyn S; Cardona-Galeano, W; Quintero-Saumeth, J; Sierra, K; Osorio, E; Gonzalez-Molina, LA; Posada-Duque, R*; Yepes, AF*. (2022). ACS Chemical Neuroscience,13,18,2681-2698,2022, American Chemical Society.

Discovery of novel neuroprotective cinnamoyl-M30D hybrids targeting Alzheimer’s disease Rada, M.S., Cardona-G, W., Sierra, K., Osorio E., Gonzalez-Molina L.A., Posada-Duque, R., *; Yepes, AF*. (2022) Medicinal Chemistry Research. 31, 1974–1989. - https://doi.org/10.1007/s00044-022-02964-1

Discovery of novel donepezil-M30D hybrids with neuroprotective properties for Alzheimer’s disease treatment. Yepes, AF*, Ramírez CA; Rada MS; Cardona-G W; Sierra K; Osorio E; Luis Alfonso Gonzalez-Molina; Posada-Duque R. (2022). Medicinal Chemistry Research. - https://doi.org/10.1007/s00044-022-02886-y

Discovery of novel donepezil-M30D hybrids with neuroprotective properties for Alzheimer’s disease treatment. Yepes, AF*, Ramírez CA; Rada MS; Cardona-G W; Sierra K; Osorio E; Luis Alfonso Gonzalez-Molina; Posada-Duque R. (2022). Medicinal Chemistry Research. - https://doi.org/10.1007/s00044-022-02886-y

Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection. (2022). Henao‐Restrepo, J; López‐Murillo, C**; Valderrama‐Carmona, P**; Orozco‐Santa, N**; Gomez J, Gutiérrez‐Vargas J, Moraga R, Toledo J, Lisa Littau J, Härtel S, Arboleda-Velásquez JF, Sepulveda-Falla D, Lopera F, Cardona-Gómez GP, Villegas Andrés, Posada-Duque R. (2022) Brain Pathology,e13119. - https://doi.org/10.1111/bpa.13119

López-Murillo C, Hinestroza-Morales S**, Henny P, Toledo J, Cardona-Gómez GP, Rivera-Gutiérrez H, Posada-Duque R. Differences in vocal brain areas and astrocytes between the House Wren and the Rufous-tailed Hummingbird. 2024. Frontiers in Neuroanatomy. 18 - https://doi: 10.3389/fnana.2024.1339308

Equipo

Yaneth Miranda

Isaura María Suárez Uribe_Est Maestría

Isaura María Suárez

Lina Gisela Pineda

Lina Gisela Pineda

José Alejando Ossa - Estudiante de Pregrado

José Alejandro Ossa

Salomé López

Juan Esteban Cano Franco_Est pregrado

Juan Esteban Cano

Estudiante de Pregrado
Santiago Hinestroza

Santiago Hinestroza

  • Estudiante de Pregrado – Actual Investigador
  • Ver CvLac
Hernán Hoyos

Hernán Hoyos

Valeria Zapata Tobón

Valeria Zapata

Estudiante de Pregrado